Internet Archive Scholar

Pan-Genome Analysis of Human Gastric PathogenH. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets

Amjad Ali, Anam Naz, Siomar C Soares, Marriam Bakhtiar, Sandeep Tiwari, Syed S Hassan, Fazal Hanan, Rommel Ramos, Ulisses Pereira, Debmalya Barh, Henrique César Pereira Figueiredo, David W. Ussery (+3 others)
2015 BioMed Research International  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (2.5 MB)
https://web.archive.org/web/20190227043915/http://pdfs.semanticscholar.org/8a2b/6462bb88f92ad9f17410d92dc7e8d460dcc9.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL. The file type is application/pdf.

Helicobacter pyloriis a human gastric pathogen implicated as the major cause of peptic ulcer and second leading cause of gastric cancer (~70%) around the world. Conversely, an increased resistance to antibiotics and hindrances in the development of vaccines againstH. pyloriare observed. Pan-genome analyses of the global representativeH. pyloriisolates consisting of 39 complete genomes are presented in this paper. Phylogenetic analyses have revealed close relationships among geographically
more » ... e strains ofH. pylori. The conservation among these genomes was further analyzed by pan-genome approach; the predicted conserved gene families (1,193) constitute ~77% of the averageH. pylorigenome and 45% of the global gene repertoire of the species. Reverse vaccinology strategies have been adopted to identify and narrow down the potential core-immunogenic candidates. Total of 28 nonhost homolog proteins were characterized as universal therapeutic targets againstH. pyloribased on their functional annotation and protein-protein interaction. Finally, pathogenomics and genome plasticity analysis revealed 3 highly conserved and 2 highly variable putative pathogenicity islands in all of theH. pylorigenomes been analyzed.
doi:10.1155/2015/139580 pmid:25705648 pmcid:PMC4325212 fatcat:ino77adj4zcwljkuuodz7shr6q
DOAJ
Citation

Amjad Ali, Anam Naz, Siomar C Soares, Marriam Bakhtiar, Sandeep Tiwari, Syed S Hassan, Fazal Hanan, Rommel Ramos, Ulisses Pereira, Debmalya Barh, Henrique César Pereira Figueiredo, David W. Ussery, Anderson Miyoshi, Artur Silva, Vasco Azevedo. "Pan-Genome Analysis of Human Gastric PathogenH. pylori: Comparative Genomics and Pathogenomics Approaches to Identify Regions Associated with Pathogenicity and Prediction of Potential Core Therapeutic Targets." BioMed Research International (2015) 1-17