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Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression anddoi:10.7554/elife.30334 pmid:29376822 pmcid:PMC5812713 fatcat:f4pkjrziinhalaoqzi5xf62ao4