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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
2015
Nature Genetics
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse ES cell knockout resource provides a basis for characterisation of relationships between gene and phenotype. The EUMODIC consortium developed and validated robust methodologies for broad-based phenotyping of knockouts through a pipeline comprising 20 disease-orientated platforms. We developed novel statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes
doi:10.1038/ng.3360
pmid:26214591
pmcid:PMC4564951
fatcat:mbfwpaop3fh45p5fn2t4zwme6a