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RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse
2021
Journal of Clinical Investigation
Slow-cycling/dormant cancer cells (SCCs) have pivotal roles in driving cancer relapse and drug resistance. A mechanistic explanation for cancer cell dormancy and therapeutic strategies targeting SCCs are necessary to improve patient prognosis, but are limited because of technical challenges to obtaining SCCs. Here, by applying proliferation-sensitive dyes and chemotherapeutics to non-small cell lung cancer (NSCLC) cell lines and patient-derived xenografts, we identified a distinct SCC
doi:10.1172/jci136779
pmid:33393490
fatcat:op5pq2wwqjhm3giiuyzfqhovke