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Profiling genome-wide methylation in two maples: fine-scale approaches to detection with nanopore technology
[article]
2022
bioRxiv
pre-print
ABSTRACTDNA methylation is critical to the regulation of transposable elements and gene expression. Traditional methods of methylation quantification rely on bisulfite conversion, which requires treatments to the DNA that can compromise accuracy. Recent advances in long-read sequencing technologies allow for methylation detection in real time. The associated algorithms that interpret these modifications have evolved from strictly statistical approaches to Hidden Markov Models and, recently,
doi:10.1101/2022.08.02.502577
fatcat:orqnulnjsre6hiktmfo7rpy77m