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We present a new fast active-contour model (a.k.a. snake) for image segmentation in 3D microscopy. We introduce a parametric design that relies on exponential B-spline bases and allows us to build snakes that are able to reproduce ellipsoids. We design our bases to have the shortest-possible support, subject to some constraints. Thus, computational efficiency is maximized. The proposed 3D snake can approximate blob-like objects with good accuracy and can perfectly reproduce spheres anddoi:10.1109/tip.2013.2264680 pmid:23708807 fatcat:bzkc776w5jgpvlqdhapi7wkojy