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Only 4 classes of antifungal agents comprising 9 compounds are eŠective against deep mycosis in Japan, and it has been di‹cult to develop new antifungal speciˆc agents. Micafungin, which has been used as an antifungal agent since 2002, inhibits b-1,3-glucan synthesis in fungal cell walls, thereby killing yeast andˆlamentous fungi with no septum. In this study, we constructed a pYES2-BGL2 vector to overexpress b-1,3-glucanase (BGL2) in yeast (Saccharomyces cerevisiae INVSc1) and evaluated thedoi:10.1248/yakushi.17-00197 pmid:29863056 fatcat:kwhawsn77jfv3jgfu3xlfvg4hm