Effect of Exercise on Lipid Profile and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

R.A. Ngala, Osei Sadique, P.K. Gmagna
2013 American Journal of Drug Discovery and Development  
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and insulin action or both. The chronic hyperglycemia is associated with long-term damage, dysfunction, and failure of normal functioning of various organs. Hyperglycaemia generates oxidative stress and progressive inflammation due to organ damage. In this study, we have analysed the serum levels of some oxidative and inflammatory markers and Lipid profile in newly
more » ... file in newly diagnosed type 2 diabetes patients. Methods: Case-control study comprising of aged-sex matched subjects: newly diagnosed T2DM cases (n=30) and controls (n=30). The serum samples of subjects were analysed for levels of CRP by turbidimetry, MDA by Buege and Aust method, while NO levels by Cortas and Wakid's kinetic cadmium reduction method using spectrophotometer. Lipid profile was analysed using agarose gel electrophoresis. Statistical analysis was done using Mini-tab 17 software with 95% confidence interval. Results: In comparison to healthy controls, serum levels of MDA and NO in T2DM patients were significantly increased. Serum CRP was significantly increased. The lipid profile was significantly affected with decrease in VLDL and Chylomicron, while increase in LDL levels. Levels of HDL and Lipoprotein (a) were unaffected. Conclusion: There is increased inflammatory and oxidative stress in type 2 diabetes which affects the lipid profile and dysfunction of body organs causing disease progression. Lipid profile and lipoprotein (a) analysis with antioxidant supplements might help control and keep check on disease status.
doi:10.3923/ajdd.2013.23.31 fatcat:4n7752lkrrczbcywcvbunj4vo4