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Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles
2017
PLoS Genetics
HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has uncovered an unprecedented number of novel HLA class I alleles. Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. This analysis required development of suites of methods, having general applicability, for comparing and analyzing large numbers of homologous
doi:10.1371/journal.pgen.1006862
pmid:28650991
pmcid:PMC5507469
fatcat:ozspuiacs5hsdmodrbsgmprg64