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Lipopolysaccharides of Gram-Negative Bacteria: Biosynthesis and Structural Aspects
Trends in glycoscience and glycotechnology
Gram-negative bacteria are to a large extent covered by lipopolysaccharide (LPS) anchored in the outer leaflet of their outer membrane. There are presently four described pathways for the O-antigen assembly of LPS, viz., synthase-, Wzk-, ABC-transporterand Wzx/Wzy-dependent pathways, where the latter two are used in Escherichia coli, subject to the O-antigen polysaccharide to be made. NDP-sugar monosaccharides are used by glycosyltransferases in the process of linking sugar residues together indoi:10.4052/tigg.1749.7e fatcat:iclngy3twje3zhgzshymms6bwu