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Transcriptome innovations in primates revealed by single-molecule long-read sequencing
AbstractTranscriptomic diversity greatly contributes to the fundamentals of disease, lineage-specific biology, and environmental adaptation. However, much of the actual isoform repertoire contributing to shaping primate evolution remains unknown. Here, we combined deep long- and short-read sequencing complemented with mass spectrometry proteomics in a panel of lymphoblastoid cell lines (LCLs) from human, three other great apes, and rhesus macaque, producing the largest full-length isoformdoi:10.1101/2021.11.10.468034 fatcat:dldsbxmgmbdmbliuzsbm7n5ezy