Cross-species Analysis Reveals Evolving and Conserved Features of the Nuclear Factor κB (NF-κB) Proteins

Grigory Ryzhakov, Ana Teixeira, David Saliba, Katrina Blazek, Tatsushi Muta, Jiannis Ragoussis, Irina A. Udalova
<span title="2013-03-18">2013</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
NF-B regulates transcription via binding to DNA and interactions with cofactors. Results: NF-B binding to DNA and cytosolic IBs is conserved, whereas binding to nuclear IBs has evolved. Conclusion: There is distinct evolutionary pressure on two NF-B/IB binding interfaces. Significance: The results provide inroads into IB-specific modulation of NF-B activity.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1074/jbc.m113.451153">doi:10.1074/jbc.m113.451153</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23508954">pmid:23508954</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3630861/">pmcid:PMC3630861</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/a5jmfg36ijhkzgchrim5urhfdm">fatcat:a5jmfg36ijhkzgchrim5urhfdm</a> </span>
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