Cross-species Analysis Reveals Evolving and Conserved Features of the Nuclear Factor κB (NF-κB) Proteins

Grigory Ryzhakov, Ana Teixeira, David Saliba, Katrina Blazek, Tatsushi Muta, Jiannis Ragoussis, Irina A. Udalova
<span title="2013-03-18">2013</span> <i title="American Society for Biochemistry &amp; Molecular Biology (ASBMB)"> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of Biological Chemistry</a> </i> &nbsp;
NF-B regulates transcription via binding to DNA and interactions with cofactors. Results: NF-B binding to DNA and cytosolic IBs is conserved, whereas binding to nuclear IBs has evolved. Conclusion: There is distinct evolutionary pressure on two NF-B/IB binding interfaces. Significance: The results provide inroads into IB-specific modulation of NF-B activity.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1074/jbc.m113.451153</a> <a target="_blank" rel="external noopener" href="">pmid:23508954</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC3630861</a> <a target="_blank" rel="external noopener" href="">fatcat:a5jmfg36ijhkzgchrim5urhfdm</a> </span>
<a target="_blank" rel="noopener" href="" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href=""> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / </button> </a> <a target="_blank" rel="external noopener" href="" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> </button> </a>