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Cross-species Analysis Reveals Evolving and Conserved Features of the Nuclear Factor κB (NF-κB) Proteins
<span title="2013-03-18">2013</span>
<i title="American Society for Biochemistry & Molecular Biology (ASBMB)">
<a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mryncoafc5cxdicldzfm4vlsze" style="color: black;">Journal of Biological Chemistry</a>
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NF-B regulates transcription via binding to DNA and interactions with cofactors. Results: NF-B binding to DNA and cytosolic IBs is conserved, whereas binding to nuclear IBs has evolved. Conclusion: There is distinct evolutionary pressure on two NF-B/IB binding interfaces. Significance: The results provide inroads into IB-specific modulation of NF-B activity.
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