A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is
Faculty Opinions recommendation of Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Ablation of LGR5 + intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescent 'reserve' ISCs contribute toward regeneration. By timing the interval between LGR5 + lineage tracing and lethal injury, we show that ISC regeneration is explained nearlydoi:10.3410/f.737406584.793577718 fatcat:dguicoj4cngi5ksfe25wx4yynm