High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children

Yaneth C Orbe-Orihuela, Alfredo Lagunas-Martínez, Margarita Bahena-Román, Vicente Madrid-Marina, Kirvis Torres-Poveda, Eugenia Flores-Alfaro, Araceli Méndez-Padrón, Cinthya E Díaz-Benítez, Oscar Peralta-Zaragoza, Diana Antúnez-Ortiz, Miguel Cruz, Ana I Burguete-García
2017 Salud Pública de México  
High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children. Salud Publica Mex 2018;60:5-11. Abstract Objective. To investigate the correlation among pro-or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children. Materials and methods. Anthropometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut
more » ... ce of gut microbiota in feces was evaluated by quantitative Real-Time PCR assays. Results. Anthropometric and biochemical parameters were statistically higher in overweight /obese children than in lean ones. Increased TNF-α levels were found in obese children that also have a high relative abundance of Firmicutes. Conclusions. Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF-α. This is the first study that shows a relation between Firmicute abundance and TNF-α serum concentration in obese children.
doi:10.21149/8133 pmid:29689651 fatcat:eqeiijk3pnfrnaww27uuuucqcm