Bacteriological profile and antibiotic susceptibility of neonatal sepsis in a tertiary care hospital

Dr. Shubhangi Kedar, Dr. Anjali Parekh
2020 International Journal of Paediatrics and Geriatrics  
Neonatal septicemia is a significant cause of morbidity and mortality worldwide, especially so in developing countries. The present study was undertaken to determine the bacteriological profile and their antimicrobial susceptibility patterns of prevalent pathogens isolated from the blood of septicemic neonates. Methods: A retrospective observational study was conducted in the NICU of a tertiary care hospital. The study duration was 24 months, from January 2018 to December 2019. All
more » ... 9. All culture-positive neonatal cases were studied. Blood culture isolates, their susceptibility, and clinical outcomes were collected. Results: Of the 105 blood samples from neonates with suspected sepsis, septicemia could be confirmed by culture in 31.42% of cases. Of the total cases 45.46%, were of early onset septicemia and 54.54% were of late-onset sepsis. In the present study, gram-negative organisms predominated being responsible for 75.75% of cases of septicemia. Klebsiella pneumoniae was found to be the predominant pathogen, followed by Acinetobacter spp. accounting for 33.33% and 18.18% of cases, respectively. Coagulase-negative Staphylococcus 12.12% was a common pathogen in gram-positive isolates. Maximum sensitivity for ciprofloxacin, amikacin, and chloramphinicol was exhibited for K. pneumoniae (63.63%, 63.63%, and 81.81%, respectively,). Amikacin and chloramphinicol were sensitive, even in the rest of the gram-negative isolates. Staphylococci aureus strains, including MRSA, methicillin-resistant staphylococci aureus were 100% sensitive to vancomycin in our setup. Conclusions: This study highlights the predominance of gram-negative organisms in neonatal sepsis and the emergence of multidrug resistance of gram-positive and gram-negative organisms to commonly used antibiotics. To understand and prevent the emergence of resistant organism's, periodic surveillance of organisms and their antibiotic sensitivity patterns are essential.
doi:10.33545/26643685.2020.v3.i1c.76 fatcat:2cla6tw45faedcmwrj7n6d33qa