A 8-Week, Randomized, Double-Blind, Placebo-Controlled Human Trial to Evaluate the Efficacy and Safety of Punica granatum L.ㆍ Actinidia chinensis Planch. Mixed Extract on Body Fat

Jin-Bong Choi, Ji-Eun Lee, Yun-Kyoung Do
2017 Journal of Korean Medicine for Obesity Research  
Objectives: This study was conducted to evaluate efficacy and safety of Punica granatum L.ㆍ Actinidia chinensis Planch. mixed extract on body fat. Methods: Thirty women were recruited (25 kg/m 2 ≤body mass index [BMI]≤29.9 kg/m 2 ) (19 yr≤ age≤38 yr) and randomized to receive Punica granatum L.ㆍActinidia chinensis Planch. mixed extract or placebo for 8 weeks. During the test, they visited four times including screening. Body fat mass, body fat rate, anthropometric dimensions at waist and hip,
more » ... ist-hip ratio, total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) were measured at screening and 8 weeks after screening. Adverse reaction were also checked each visit. Results: There were no significant differences in all index. But when divide experimental group by BMI index, age, and compliance, less than BMI 27 kg/m 2 group decreased body weight, body fat mass and more than BMI 27 kg/m 2 group also decreased body weight, body fat mass and waist circumference. Less than age 30 years group showed decline of waist circumference, fat free rate and T-cholesterol and more than age 30 years group showed decline of fat free mass. Group with compliance more than 95% was decreased BMI, fat free mass, and hip circumference. Conclusions: There was no significant efficacy as compared with placebo group, but as divide experimental group according to BMI index, age, compliance, mixed extract might be effective to reduce obesity index.
doi:10.15429/jkomor.2017.17.2.87 fatcat:pisx2wkl7zfd3f4ubuhgeggd5y