REVIEW: Pandangan Baru Kurkumin dan Aktivitasnya sebagai Antikanker REVIEW: The new paradigm of curcumin and its anticancer activity ARIEF NURROCHMAD ♥

Laboratorium Farmakologi, Dan Toksikologi, Bagian Farmakologi, Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah, Mada, Sekip Utara, Yogyakarta
2004 Biofarmasi   unpublished
Curcumin, derived from the rhizome of Curcuma longa L. is used as a coloring and flavoring additive in many foods and has attracted interest because of its antioxidant activity, antiinflammatory and chemopreventive activities. Various curcumin-related phenols have also been found in edible or medicinal plants, especially in Zingiberaceae. Curcumin has a unique conjugated structure including two methoxylated phenols and an enol form of β-diketone, and the structure shows a typical radical
more » ... ical radical trapping ability as a chain-breaking antioxidant. Curcumin has demonstrated anticarcinogenic effects in numerous animal models including skin and gastrointestinal carcinomas. Curcumin also inhibited benzo[a]pyren-or DMBA (7,12-dimethylbenz[a]anthracene)-induced skin cancer in a mice carcinogenesis model. Curcumin inhibits chemically induced carcinogenesis in the skin, forestomach, and colon when it is administered during initiation and/or postinitiation stages. Curcumin directly inhibited the activity of COX-2. The anti-inflammatory properties of curcumin have been attributed, at least in part, to suppression of PG synthesis. Curcumin also inhibited COX-2 transcription in bile acid and phorbol ester-treated gastrointestinal cell lines. Additionally, administration of curcumin into the rats during the initiation and postinitiation stages and throughout the promotion/progression stage increased apoptosis in the colon tumors. This article provide a mechanistic basis for the antioxidant, chemopreventive and antiinflammatory related-anticancer properties of curcumin.