Organocatalytic regioselective asymmetric Michael addition of azlactones to o-hydroxy chalcone derivatives

Shao-Yun Zhang, Gui-Yu Ruan, Zhi-Cong Geng, Nai-Kai Li, Ming Lv, Yong Wang, Xing-Wang Wang
2015 Organic and biomolecular chemistry  
Regio- and enantio-selective Michael addition between azlactones with o-hydroxy chalcone derivatives is reported. Optically active N,O-aminals are obtained in good yields with good to excellent diastereo- and enantio-selectivities.
doi:10.1039/c5ob00121h pmid:25897737 fatcat:bwmxqbsiezbs3oz5gupr4jm37y