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Expression of the RET oncogene induces differentiation of SK-N-BE neuroblastoma cells
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Expression of the RET proto-oncogene, a cell surface receptor for an as yet unknown ligand, is associated with tumors, tissues, and cell lines of neural crest origin. Accumulating evidence suggests that RET activity is involved in the process of neuronal differentiation. Moreover, induction of phenotypic differentiation of neuroblastoma cell lines is associated with the rapid accumulation of RET transcripts. To verify the role of RET in neuronal differentiation, we introduced into the humanpmid:8562477 fatcat:vjsuoyiccbbkrkc3f4pkugfiye