Biobased Hyperbranched Poly(ester)s of Precise Structure for the Release of Therapeutics

Bob Howell, Tracy Zhang, Patrick Smith
2021 Medical Research Archives  
Hyperbrached poly(ester)s derived from naturally-occurring biomonomers may serve as excellent platforms for the sustained-release of therapeutics. Those generated from glycerol are particularly attractive. Traditionally, the difference in reactivity of the hydroxyl groups of glycerol has precluded the formation of well-defined polymers at high monomer conversion without gelation. Using the Martin-Smith model to select appropriate monomer ratios (ratios of functional groups), polymerization may
more » ... polymerization may be carried out to high conversion while avoiding gelation and with the assurance of a single type of endgroup. Various agents may be attached via esterification, amide formation or other process. Sustained release of the active agent may be readily achieved by enzyme-catalyzed hydrolysis.
doi:10.18103/mra.v9i1.2308 fatcat:iugy2ujdnveedlqv3oyrzvzcd4