Neuro-ophthalmologic aspects of multiple sclerosis: Using eye movements as a clinical and experimental tool

Annette Niestroy, Janet Rucker, R Leigh
2007 Clinical Ophthalmology   unpublished
Ocular motor disorders are a well recognized feature of multiple sclerosis (MS). Clinical abnormalities of eye movements, early in the disease course, are associated with generalized disability, probably because the burden of disease in affected patients falls on the brainstem and cerebellar pathways, which are important for gait and balance. Measurement of eye movements, especially when used to detect internuclear ophthalmoplegia (INO), may aid diagnosis of MS. Measurement of the ocular
more » ... f the ocular following response to moving sinusoidal gratings of specifi ed spatial frequency and contrast can be used as an experimental tool to better understand persistent visual complaints in patients who have suffered optic neuritis. Patients with MS who develop acquired pendular nystagmus often benefi t from treatment with gabapentin or memantine.