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Detecting oncogenic selection through biased allele retention in The Cancer Genome Atlas
[article]
2020
bioRxiv
pre-print
The loss of genetic diversity in segments over a genome (loss-of-heterozygosity, LOH) is a common occurrence in many types of cancer. By analysing patterns of preferential allelic retention during LOH in approximately 10,000 cancer samples from The Cancer Genome Atlas (TCGA), we sought to systematically identify genetic polymorphisms currently segregating in the human population that are preferentially selected for, or against during cancer development. Experimental batch effects and
doi:10.1101/2020.07.03.186593
fatcat:c7m7jn5uo5gwpbfpkwbyq2qfiy