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TNF -Mediated Inhibition and Reversal of Adipocyte Differentiation Is Accompanied by Suppressed Expression of PPAR without Effects on Pref-1 Expression
Tumor necrosis factor ␣ (TNF␣) is a polypeptide hormone with pleiotropic effects on cellular proliferation and differentiation. To investigate how TNF␣ inhibits and reverses adipocyte differentiation, we studied the expression of two factors involved in the adipocyte differentiation process. Peroxisome proliferator-activated receptor ␥ (PPAR␥) is a positive regulator of adipogenesis, whereas preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. The expression patterns of both PPAR␥doi:10.1210/en.138.7.2776 pmid:9202217 fatcat:4fm4s4fpkzbcpc4ctt7i2uhmte