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Identification of Potential Inhibitors against the Human Influenza A Virus Targeting the CPSF30 and RNA Binding Domains of the NS1 Protein: An E-Pharmacophore approach
2017
Indian Journal of Pharmaceutical Education and Research
Common occurrences of influenza virus strains resistant to known neuraminidase and matrix protein inhibitors like oseltamivir and amantadine respectively necessitate the development of newer antivirals. The virus' non-structural protein (NS1) through its effector domain (ED) and RNA binding domain (RBD) plays significant roles in overcoming the host antiviral response and regulating the virus replication cycle respectively. Aim: This work attempts to identify potential NS1 based inhibitors
doi:10.5530/ijper.51.1.5
fatcat:pyjo4jcmnvffdajteqggpdao5u