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Constitutive Activation of the δ Opioid Receptor by Mutations in Transmembrane Domains III and VII
1999
Journal of Biological Chemistry
We have investigated whether transmembrane amino acid residues Asp 128 (domain III), Tyr 129 (domain II), and Tyr 308 (domain VII) in the mouse ␦ opioid receptor play a role in receptor activation. To do so, we have used a [ 35 S]GTP␥S (where GTP␥S is guanosine 5-3-O-(thio)triphosphate) binding assay to quantify the activation of recombinant receptors transiently expressed in COS cells and compared functional responses of D128N, D128A, Y129F, Y129A, and Y308F point-mutated receptors to that of
doi:10.1074/jbc.274.26.18574
pmid:10373467
fatcat:uufeoj67qzg5hjnehvf7xhaamy