Focal Adhesion-Independent Cell Migration

Ewa Kamila Paluch, Irene M Aspalter, Michael Sixt, Apollo-University Of Cambridge Repository
Cell migration is central to a multitude of physiological processes including embryonic development, immune surveillance and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration. Together with protrusion extension and cell body retraction, adhesion to the substrate via specific focal adhesions points has long been considered an essential step in cell migration.
more » ... cell migration. While this is true for cells moving on two-dimensional substrates, recent studies have demonstrated that focal adhesions are not required for cells moving in three dimensions, where confinement is sufficient to maintain a cell in contact with its substrate. Here, we review the investigations that have led to challenging the requirement of specific adhesions for migration, discuss the physical mechanisms proposed for cell body translocation during focal-adhesion-independent migration, and highlight the remaining open questions for the future.
doi:10.17863/cam.54624 fatcat:xu5jdzpkijhx3lflh4ljmxzibm