Lipoidial profile of Ipomoea tricolor and Ipomoea fistulosa leaves were characterized by GC/MS led to the identification of 22 and 33 compounds represented (95.88 and 91.82 %), respectively, of I. tricolor and I. fistulosa unsaponifiable matter It is composed mainly of hydrocarbons and oxygenated compounds. The GC/MS of fatty acids methyl ester (FAME) led to the identification of 8 and 10 compounds for I. tricolor and I. fistulosa, respectively.Linolenic and palmatic acids were found as the

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... ominant fatty acids. On the other hand, the petroleum ether extract of I.tricolor was fractionated on column chromatography to yield major compounds; 5-phenyldecane and 4-phenyldecane, as well as, triterpenes including β-amyrin, lupeol and simiarenol,in addition to αamyrin, β-sitosterol, stigmasterol and αamyrin acetate which isolated for the first time from this species.The petroleum ether extracts of I. tricolorand I. fistulosa showed a significant increase in DPPHinhibition activity at 0.01 and 0.05 ug/ml, respectively. Furthermore, I.tricolor extract exhibited a significant increase in cholinesterase inhibition activity at concentration 20 ug/ml and a significant anti-inflammatory activity with IC50 117.4µg/ml. It can be concluded that pet.ether extracts of I.tricolor and I.fistulosa at different concentrations have significant antioxidant, anticholinesterase and antiinflammatory activities related to various bioactive identified compounds.