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Single cell membrane poration by bubble-induced microjets in a microfluidic chip
Lab on a Chip
This paper demonstrates membrane poration of a single suspension cell due to a fast liquid microjet. The jet is formed during the collapse of a laser induced bubble created at a variable stand-off distance from the target cell. The cell is trapped by a converging structure within a microfluidic chip. The asymmetrical growth and collapse of the cavitation bubble next to the cell lead to the microjetting, which deforms and porates the cell membrane. In the experiments, the membrane porations ofdoi:10.1039/c3lc41252k pmid:23364762 fatcat:dqup2m2t5zfdvdg7vrqi55m6pm