Role of Multiple-Scale Modeling of Epilepsy in Seizure Forecasting

Levin Kuhlmann, David B. Grayden, Fabrice Wendling, Steven J. Schiff
2015 Journal of clinical neurophysiology  
Over the past three decades, a number of seizure prediction, or forecasting, methods have been developed. Although major achievements were accomplished regarding the statistical evaluation of proposed algorithms, it is recognized that further progress is still necessary for clinical application in patients. The lack of physiological motivation can partly explain this limitation. Therefore, a natural question is raised: can computational models of epilepsy be used to improve these methods? Here
more » ... e review the literature on the multiple-scale neural modelling of epilepsy and the use of such models to infer physiological changes underlying epilepsy and epileptic seizures. We argue how these methods can be applied to advance the state-of-the-art in seizure forecasting. Glossary LFP local field potential EEG electroencephalography iEEG intracranial electroencephalography K + potassium ion Na+ sodium ion GABA gamma-aminobutyric acid CA1 hippocampus, Cornu Ammonis area 1 PSP post-synaptic potential TLE temporal lobe epilepsy Kuhlmann et al.
doi:10.1097/wnp.0000000000000149 pmid:26035674 pmcid:PMC4455036 fatcat:oiime3h2ejdslajqib45ggqaoa