An Impaired Natriuretic Peptide Hormone System May Play a Role in COVID-19 Severity in Vulnerable Populations: A Hypothesis [post]

Mark G. Currie, Daniel Zimmer, Perry Halushka
2020 unpublished
Advanced age, underlying cardiovascular disease (including hypertension), and obesity are associated with a higher risk of progression to severe hypoxemia, acute respiratory distress syndrome (ARDS), and death in COVID-19-infected patients; African Americans have a higher degree of COVID-19 mortality. The incidence of salt sensitive hypertension is higher in older individuals and African Americans. Lower circulating levels of natriuretic peptides, key regulators of vascular tone and kidney
more » ... ion, have been associated with salt-sensitive hypertension and obesity. Evidence has accumulated that the cardiac-derived atrial natriuretic peptide (ANP) administered to pulmonary endothelial cells, isolated lungs, and patients suffering from ARDS reduces endothelial damage and preserves the endothelial barrier, thereby reducing pulmonary edema and inflammation. Epidemiologic and pharmacologic data suggest that deficiencies in the natriuretic peptide hormone system may contribute to the development of severe lung pathology in COVID-19 patients.
doi:10.31219/osf.io/g4apd fatcat:maae7hcg7zha3nfs7eppre44b4