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Sardinians Genetic Background Explained by Runs of Homozygosity and Genomic Regions under Positive Selection
2014
PLoS ONE
The peculiar position of Sardinia in the Mediterranean sea has rendered its population an interesting biogeographical isolate. The aim of this study was to investigate the genetic population structure, as well as to estimate Runs of Homozygosity and regions under positive selection, using about 1.2 million single nucleotide polymorphisms genotyped in 1077 Sardinian individuals. Using four different methods -fixation index, inflation factor, principal component analysis and ancestry estimation
doi:10.1371/journal.pone.0091237
pmid:24651212
pmcid:PMC3961211
fatcat:xqxjhcms4bbyhmau35xg7esroi