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The peculiar position of Sardinia in the Mediterranean sea has rendered its population an interesting biogeographical isolate. The aim of this study was to investigate the genetic population structure, as well as to estimate Runs of Homozygosity and regions under positive selection, using about 1.2 million single nucleotide polymorphisms genotyped in 1077 Sardinian individuals. Using four different methods -fixation index, inflation factor, principal component analysis and ancestry estimationdoi:10.1371/journal.pone.0091237 pmid:24651212 pmcid:PMC3961211 fatcat:xqxjhcms4bbyhmau35xg7esroi