In vivo preclinical verification of a multimodal diffuse reflectance and correlation spectroscopy system for sensing tissue perfusion

Julia M. Pakela, Seung Yup Lee, Taylor L. Hedrick, Karthik Vishwanath, Michael C. Helton, Yooree G. Chung, Noah J. Kolodziejski, Christopher J. Staples, Daniel R. McAdams, Daniel E. Fernandez, James F. Christian, Jameson O'Reilly (+5 others)
2017 Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics  
In reconstructive surgery, impeded blood flow in microvascular free flaps due to a compromise in arterial or venous patency secondary to blood clots or vessel spasms can rapidly result in flap failures. Thus, the ability to detect changes in microvascular free flaps is critical. In this paper, we report progress on in vivo pre-clinical testing of a compact, multimodal, fiber-based diffuse correlation and reflectance spectroscopy system designed to quantitatively monitor tissue perfusion in a
more » ... cine model's surgically-grafted free flap. We also describe the device's sensitivity to incremental blood flow changes and discuss the prospects for continuous perfusion monitoring in future clinical translational studies.
doi:10.1117/12.2252620 pmid:29706683 pmcid:PMC5916836 fatcat:4prboiry3zam7epnowdihaencq