Signal Transducer and Activator of Transcription 3 Activates CCAAT Enhancer-binding Protein δ Gene Transcription in G0Growth-arrested Mouse Mammary Epithelial Cells and in Involuting Mouse Mammary Gland

Julie A. Hutt, John P. O'Rourke, Jim DeWille
2000 Journal of Biological Chemistry  
The CCAAT enhancer-binding protein (C/EBP) family of transcription factors is implicated in the regulation of cell proliferation and differentiation in a variety of tissues. C/EBP␦ is involved in regulating G 0 growth arrest and apoptosis of mouse mammary epithelial cells. This study shows that activation of signal transducer and activator of transcription 3 (Stat3), but not activation of Stat1 or Stat5, occurs concurrently with G 0 growth arrest of HC11 mouse mammary epithelial cells, but not
more » ... IH 3T3 fibroblasts. Promoter analysis demonstrates that the C/EBP␦ promoter fragment involved in transcriptional activation during G 0 growth arrest contains a Stat3 binding site and that mutation of this site eliminates the G 0 growth arrest inducibility of the C/EBP␦ promoter.
doi:10.1074/jbc.m004476200 pmid:10867011 fatcat:xkja53fwfzeznoig5idunmo5vu