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The Heat Shock Protein 90-Targeting Drug Cisplatin Selectively Inhibits Steroid Receptor Activation
2003
Molecular Endocrinology
Cisplatin is an antineoplastic drug that binds to DNA, thereby inhibiting cell division and tumor growth. Cisplatin may also disrupt the function of some proteins, including heat shock protein 90 (Hsp90). We report that cisplatin dose-dependently inhibited transcriptional activity of the androgen receptor and the glucocorticoid receptor (GR) in transient reporter assays. A truncated, hormoneindependent GR was only partially inhibited at significantly higher doses of cisplatin. Cisplatin
doi:10.1210/me.2003-0141
pmid:12869591
fatcat:dfkbgmsdzjeqldhg2kltjqi6oy