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Disulfide Bonds Are Generated by Quinone Reduction
Journal of Biological Chemistry
The chemistry of disulfide exchange in biological systems is well studied. However, very little information is available concerning the actual origin of disulfide bonds. Here we show that DsbB, a protein required for disulfide bond formation in vivo, uses the oxidizing power of quinones to generate disulfides de novo. This is a novel catalytic activity, which to our knowledge has not yet been described. This catalytic activity is apparently the major source of disulfides in vivo. We developed adoi:10.1074/jbc.m003850200 pmid:10854438 fatcat:ystifthsxbc5dfiffrsy3nzbiq