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Methods for recording and imaging spreading depolarizations and seizure-like events in mouse hippocampal slices
[article]
2021
bioRxiv
pre-print
Spreading depolarization (SD) is a sudden and synchronized depolarization of principal cells followed by depression of activity, which slowly propagates across brain regions like cortex or hippocampus. SD is considered to be mechanistically relevant to migraine, epilepsy, and traumatic brain injury. Interestingly, research into SD typically uses SD triggered immediately after a focal stimulus. Here we optimize an in vitro experimental model allowing us to record SD without focal stimulation.
doi:10.1101/2021.08.19.457007
fatcat:markuoztdbgyrebwynj4wru2bi