Bence Jones (kappa) type myeloma associated with systemic amyloidosis occurred in a 71-year-old man. He had pruritic yellowish papules over the almost whole body, purpuric lesions on the both internal canthi, and subcutaneous nodules on the outside of both thighs. Dysphagia, hoarseness, gait disturbance, rigidity of the both shoulder and tongue, disturbance of opening mouth had appeared. Histopathological examinations showed eosinophilic amorphous materials at the subepidermal layer, which was

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... ositive with anti-AL K chain anti-body staining. Bence-Jones protein K type was found in the serum and urine. In smear samples of the bone marrow, the plasma cell occupied 17.5%, and there was a high differentiation type of myeloma cells, too. Cutaneous lesions flattened following topical applications of dimethylsulfoxide(DMS0) Oral melphalan-prednisolone treatment was done without any improvement for 7 days, and pancytopenia were gradually manifested, and he passed away 10 days later. Autopsy was not carried out.