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Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers
2018
Genes
In Metazoans, transcription of most genes is driven by the use of multiple alternative promoters. Although the precise regulation of alternative promoters is important for proper gene expression, the mechanisms that mediates their differential utilization remains unclear. Here, we investigate how the two alternative promoters (P1, P2) that drive MYC expression are regulated. We find that P1 and P2 can be differentially regulated across cell-types and that their selective usage is largely
doi:10.3390/genes9060270
pmid:29882899
pmcid:PMC6027352
fatcat:py57win4d5bofk6l4kpnnxojne