Efficacy of Pentoxifylline as an Antifibrotic Drug in Experimental Murine Schistosomal Hepatic Fibrosis

Eman Khalifa, Heba Mahmoud, Ahmad Farrag, Hala Hamouda, Amal Baalash
2007 Bulletin of Egyptian Society for Physiological Sciences  
Aim: The present study was a preliminary trial evaluating the possible antifibrotic effect of pentoxifylline on experimentally induced schistosomal hepatic fibrosis and, also, to investigate its effect on serum leptin and transforming growth factor -β1 levels as possible antifibrotic mechanisms in correlation with the hepatic fibrosis indices. Methods: In the study, ninety Swiss, laboratory bred parasite free, albino mice of both sexes were included. Ten mice served as a control non-infected,
more » ... ntreated group and sacrificed at one time. The remaining 80 mice were infected subcutaneously with 50 Schistosoma mansoni cercariae/
doi:10.21608/besps.2007.37144 fatcat:2btrfp3osbabngahxflc7o7tjy