Gestational Diabetes Mellitus Increases the Risk of Cardiovascular Disease in Women With a Family History of Type 2 Diabetes

D. B. Carr, K. M. Utzschneider, R. L. Hull, J. Tong, T. M. Wallace, K. Kodama, J. B. Shofer, S. R. Heckbert, E. J. Boyko, W. Y. Fujimoto, S. E. Kahn
2006 Diabetes Care  
OBJECTIVE -We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with firstdegree relatives with type 2 diabetes. RESEARCH DESIGN AND METHODS -Women with (n ϭ 332) and without (n ϭ 663) a history of GDM were compared regarding 1) the revised National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria, 2) the prevalence of type 2 diabetes, and 3) self-reported
more » ... RESULTS -Women with prior GDM were younger (48.6 Ϯ 0.7 vs. 52.4 Ϯ 0.6 years [means Ϯ SE]; P Ͻ 0.001) and less likely to be postmenopausal (48.3 vs. 57.9%; P Ͻ 0.005). Although both groups were obese (BMI 34.4 Ϯ 1.2 vs. 33.7 Ϯ 0.6 kg/m 2 ), women with prior GDM were more likely to have metabolic syndrome (86.6 vs. 73.5%; P Ͻ 0.001) and type 2 diabetes (93.4 vs. 63.3%; P Ͻ 0.001). Moreover, they had a higher prevalence of CVD (15.5 vs. 12.4%; adjusted odds ratio 1.85 [95% CI 1.21-2.82]; P ϭ 0.005) that occurred at a younger age (45.5 Ϯ 2.2 vs. 52.5 Ϯ 1.9 years; P ϭ 0.02) and was independent of metabolic syndrome (1.74 [1.10 -2.76]; P ϭ 0.02) and type 2 diabetes (1.56 [1.002-2.43]; P Ͻ 0.05). CONCLUSIONS -Among women with a family history of type 2 diabetes, those with prior GDM were even more likely to not only have CVD risk factors, including metabolic syndrome and type 2 diabetes, but also to have experienced CVD events, which occurred at a younger age. Thus, women with both a family history of type 2 diabetes and personal history of GDM may be especially suitable for early interventions aimed at preventing or reducing their risk of CVD and diabetes. Diabetes Care
doi:10.2337/dc05-2482 pmid:16936156 fatcat:bu6xoguolzhdxlebq34k4qzgfi