A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2006; you can also visit the original URL.
The file type is
Injection of recombinant Fc RI/CD89 in mice does not induce mesangial IgA deposition
Nephrology, Dialysis and Transplantation
Background. Earlier studies have suggested that complexes of the human IgA receptor FcaRI/CD89 with mouse IgA are pathogenic upon deposition in the renal mesangium. Transgenic mice expressing FcaRI/ CD89 on macrophages/monocytes developed massive mesangial IgA deposition and a clinical picture of IgA nephropathy (IgAN). Based on these findings, the purpose of this study was to design an experimental model of IgAN by injection of human CD89 in mice. The interaction of mouse IgA with CD89 wasdoi:10.1093/ndt/gfh459 pmid:15340093 fatcat:qjnf744lebcopix65u34ykdjj4