Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition

Johannes D. Veldhuis, James N. Roemmich, Erick J. Richmond, Cyril Y. Bowers
2006 Endocrine reviews  
Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacting mechanisms that subserve physiological adaptations and pathological disruption of reproduction and growth. Significant advances in systems biology will be needed to address these challenges.
more » ... e challenges. (Endocrine Reviews 27: 2006)
doi:10.1210/er.2005-0006 pmid:16434512 fatcat:a35ht2nso5djbmmmldqq3mzbyy