The research work intended to develop an accurate, simple, precise, sensitive and economical method for the estimation of Lafutidine (LF) and Domperidone (DP) in tablet dosage form by UV spectrophotometric method. UV spectrophotometric method includes simultaneous equations method (Method I) and Absorbance ratio method (Method II). For development of Method I wavelengths were selected for 274.0nm and 286.0 nm for estimation of LF and DP respectively. For method II, 286.0 nm λ max for DP and

more »

... 0 nm iso-absortive point of LF and DP. The two drugs follow Beers-Lamberts law over the low concentration range of 2µg-12µg/ml for LF and 3-15µg/ml for DP. The percentage estimation of the drugs was found near to 100% representing the two methods. The recovery of the LF and DP were found near to 100%. Validation of the proposed methods was carried out for its accuracy, precision and specificity according to ICH guidelines. The proposed methods can be successfully applied in routine work for the determination of LF and DP in combined dosage forms.