Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys

Martin Béhé, Gerald Kluge, Wolfgang Becker, Martin Gotthardt, Thomas M Behr
2005 Journal of Nuclear Medicine  
Uptake of radiolabeled peptides in the kidneys may obscure abdominal tumors in radiopeptide scintigraphy. This problem is much more pronounced in peptide receptor radionuclide therapy (i.e., radiopeptide therapy), possibly leading to renal damage or even failure. Cationic peptide uptake in the kidneys can be reduced by the application of cationic amino acids, such as lysine or arginine. The aim of this study was to develop a suitable method to reduce anionic peptide uptake in the kidneys.
more » ... n-Diethylenetriaminepentaacetic acid dGlu(1)-minigastrin ((111)In-DTPA-dGlu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH(2)) was chosen as a model compound with a sequence of 6 negatively charged glutamic acids in a chain and an additional aspartic acid.
pmid:15937313 fatcat:3lixtytuy5hdvcdxi2mj7vdzfq