Factors Associated with HIV-1 Proviral DNA Loads in Patients with Undetectable Plasma RNA Load

Jun Yong Choi, Young Goo Song, Young Hwa Kim, Chang Oh Kim, Myung Soo Kim, Bum Sik Chin, Sang Hoon Han, Suk Hoon Choi, Han Sung Lee, Su Jin Jeong, Heekyoung Choi, June Myung Kim
2009 Journal of Korean medical science  
To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10 6 peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/μ L without highly active antiretroviral therapy (HAART)
more » ... significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/μ L without HAART could help reduce HIV-1 proviral DNA load.
doi:10.3346/jkms.2009.24.1.152 pmid:19270829 pmcid:PMC2650966 fatcat:r6puttwdcfgyvg4ks5ufso4vlu