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Evolutionary pressure drives gut microbiota-host coevolution and results in complex interactions between gut microbiota and neural development; however, the molecular mechanisms by which the microbiota governs host behavior remain obscure. Here, we report that colonization early in life is crucial for the microbiota to modulate brain development and behavior; later colonization or deletion of microbiota cannot completely reverse the behaviors. Microarray analysis revealed an association betweendoi:10.1038/srep29998 pmid:27444685 pmcid:PMC4956747 fatcat:vtniag4tzbgsdhpu6rbel3n45m