Биосинтетические процессы в кардиомиоцитах белых крыс после введения биофлавоноида дигидрокверцетина

Сазонова Елена Николаевна, Яковенко Дарья Валерьевна, Лебедько Ольга Антоновна, Марочко Андрей Юрьеевич, Жарский Сергей Леонидович, Добрых Вячеслав Анатольевич, Рзянкина Марина Федоровна, Чепель Татьяна Владимировна
2018 Âkutskij medicinskij žurnal  
The effect of dihydroquercetin (DHA) bioflavonoid in a dose of 50 mg/kg on DNA synthesis and the state of the nucleo-nucleolar apparatus of white rat cardiomyocytes on an intact background and under conditions of oxidative stress was studied. The corrective effect of DHA on biosynthetic processes in the myocardium of white rats in the presence of oxidative stress was revealed. The effect of DHA on an intact background inhibits DNA synthetic processes in the myocardium of newborn animals and
more » ... orn animals and reduces the size of nuclei and nucleoli in cardiomyocytes of sexually mature animals. The obtained data make it possible to recommend the use of antioxidants in cardiology only in the presence of pronounced oxidative stress.
doi:10.25789/ymj.2018.63.36 fatcat:wrplnolitncljfaxaclabvisoy