HUPHO: the human phosphatase portal

S Liberti, A Calderone, F Sacco, L Perfetto, M Iannuccelli, S Panni, E Santonico, A Palma, AP Nardozza, L Castagnoli, G Cesareni
2012 EMBnet journal  
Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. Phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Thus, a comprehensive picture of phosphatase function and the identification of their target substrates would aid a systematic approach to a mechanistic description of cell signalling. Here we present a website designed to facilitate the retrieval of information about human protein
more » ... phosphatases. To this end we developed a search engine to recover and integrate information annotated in several publicly available web resources. In addition we present a text-mining-assisted annotation effort aimed at extracting phosphatase related data reported in the scientific literature. The HuPho (human phosphatases) website can be accessed at http://hupho.uniroma2.it. Abbreviations CDC14, cell division cycle 14 phosphatase; DSP, dual specificity protein phosphatase; HAD, haloacid dehalogenase; LP, lipid phosphatase; LPT, lipid phospho-transferase; MTMR, myotubularin; NUDT, nucleoside-diphosphate-linked moiety X; PPI, protein-protein interaction; PPM, metal-dependent protein phosphatase; PPP, phosphoprotein protein phosphatase; PTP, protein tyrosine phosphatase.
doi:10.14806/ej.18.a.380 fatcat:gvf4j6ktezcnnaxzvqnzmdbjn4