Objective: The objective of this study was to estimate the serum immunoglobulins (IgA, IgM, and IgG) levels, and complements (C3 and C4) level in Iraqi women with breast cancer pre-treatment and post-treatment.Methods: A total number of 100 patients aged 25–47 years were enrolled in this study, including 35 breast cancer treatment patients, 30 treatment patients, and 10 and 25 healthy women benefactor. All samples were collected from August 2016 to February 2017 from Oncology Hospital/Medical

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... ty in Baghdad exception of the control group were collected from outside the hospital. Serum levels of IgG, IgA, IgM, C3, and C4 were measured by radial immunodiffusion technique.Results: Serum mean values of IgA, IgG, and C3were significantly higher (p˂0.01) in patients pre-treatment than in post-treatment. The level of the serum for patients pre-treatment was significantly higher than post-treatment.Conclusion: The present study showed the increase of serum IgA, IgG, and C3 levels can be considered as biomarker for breast cancer diagnosis pre-treatment and post-treatment.