We studied bone mineral density (BMD), bone metabolism, and body composition in 47 children with central precocious puberty (n ‫؍‬ 36) or early puberty (n ‫؍‬ 11) before, during, and after cessation of GnRH agonist. Bone density and body composition were measured with dual energy x-ray absorptiometry and expressed as SD scores. Bone age and biochemical parameters of bone turnover were assessed. Measurements were performed at baseline, after 6 months, and on a yearly basis thereafter. Mean

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... spine BMD SD scores for chronological age were significantly higher than zero at baseline and decreased during treatment. Lumbar spine bone mineral apparent density and total body BMD did not differ from normal at baseline and showed no significant changes during treatment. In cona P Ͻ 0.01, b P Ͻ 0.001 for the comparison of the mean SD score with zero. 1 P Ͻ 0.01, 2 P Ͻ 0.001 compared with baseline. van der Sluis et al. • BMD and Body Composition in Precocious Puberty